Eyes Set to Kill emerged from the Phoenix, Arizona music scene in 2003 as a formidable force in metalcore, distinguished by the foundational partnership of sisters Alexia and Anissa Rodriguez. Originally formed with vocalist Lindsey Vogt, the band quickly established a reputation for blending aggressive instrumentation with melodic sensibilities. Following Vogt's departure, Alexia Rodriguez stepped into the dual role of lead vocalist and guitarist, a move that would define the band's evolving sound and intense live performances. Their early work culminated in the 2008 album "Reach," which served as their breakthrough claim to fame and solidified their growing fanbase.

The band's 2009 album, "The World Outside," marked a significant career milestone, earning widespread critical acclaim and elevating their profile nationally. This success led to notable features, including a cover story in USA Today and inclusion in Alternative Press Magazine's prestigious "100 Bands You Need To Know" list. Their rising prominence was further cemented when they were invited to host an episode of the iconic heavy music television program MTV's Headbangers Ball. The following year, their album "Broken Frames" was recognized locally, ranking fifth on a list of the best local albums and EPs in 2010, demonstrating their consistent output and resonance within the rock community.

Throughout their career, Eyes Set to Kill maintained a steady pace of recording and touring, navigating the changing landscape of the rock and metal genres. The lineup experienced several changes, most notably the departure of bassist and founding member Anissa Rodriguez in late 2016. This period saw the band continue to release music and perform, with Alexia remaining the constant creative driving force. In a welcome development for long-time fans, Anissa Rodriguez rejoined the band in 2023, reuniting the core sibling duo and signaling a new chapter for the group.

As a veteran act in the American metalcore scene, Eyes Set to Kill remains active, their legacy built on a foundation of powerful sisterhood, relentless touring, and a catalog that captures the aggressive and melodic extremes of their genre. Their journey from the Tempe music scene to national recognition showcases a enduring commitment to their craft, with the reunited Rodriguez sisters continuing to lead the band forward.