(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2021 | N | Best Actress in a Comedy Series | Dead to Me (2019) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | Best Actress in a Comedy Series | Dead to Me (2019) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | The Comedy TV Star of 2020 | Dead to Me (2019) (TV) | - |
| 2020 | N | The Female TV Star of 2020 | Dead to Me (2019) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | N | Outstanding Lead Actress in a Comedy Series | Samantha Who? (2007) (TV) | - |
| 2008 | N | Outstanding Lead Actress in a Comedy Series | Samantha Who? (2007) (TV) | - |
| 2004 | N | Outstanding Guest Actress in a Comedy Series; For playing "Amy" | Friends (1994) | - |
| 2003 | W | Outstanding Guest Actress in a Comedy Series; For playing "Amy". | Friends (1994) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1998 | W | Star on the Horizon | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Dead to Me (2019) (TV) | - |
| 2009 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Samantha Who? (2007) (TV) | - |
| 2008 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Samantha Who? (2007) (TV) | - |
| 1999 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Jesse (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1992 | N | Most Desirable Female | Don't Tell Mom the Babysitter's Dead (1991) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | W | Favorite Female TV Star | - | - |
| 1999 | W | Favorite Female Performer in a New Television Series | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | Outstanding Lead Actress in a Comedy Series | Dead to Me (2019) (TV) | - |
| 2019 | N | Outstanding Lead Actress in a Comedy Series | Dead to Me (2019) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Performance in a Comedy Series | Samantha Who? (2007) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Actress in a Series, Comedy or Musical | Up All Night (2011) (TV) | - |
| 2008 | N | Actress in a Series, Comedy or Musical | Samantha Who? (2007) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2020 | N | Outstanding Performance by a Female Actor in a Comedy Series | Dead to Me (2019) (TV) | - |
| 2010 | N | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? (2007) (TV) | - |
| 2009 | N | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? (2007) (TV) | - |
| 2008 | N | Outstanding Performance by a Female Actor in a Comedy Series | Samantha Who? (2007) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2014 | N | Choice Movie Actress: Comedy | Anchorman: The Legend Continues (2013) | - |
| 2008 | N | Choice TV Actress: Comedy | Samantha Who? (2007) (TV) | - |
| 2003 | N | Choice Movie Villain | View from the Top (2003) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | N | Individual Achievement in Comedy | Samantha Who? (2007) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | W | Favorite Star of a New Series | Jesse (1998) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2009 | W | - | Married with Children (1987) (TV) | David Faustino, Ted McGinley, Ed O'Neill |
| 2008 | W | Siblings That Make You Grateful for Your Own Crazy Family | Married with Children (1987) (TV) | David Faustino |
| 2004 | N | Favorite Teen Dream - Female | Married with Children (1987) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | W | - | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1992 | N | Outstanding Young Ensemble Cast in a Motion Picture | Don't Tell Mom the Babysitter's Dead (1991) | Christopher Pettiet, Danielle Harris, Keith Coogan |
| 1989 | W | Best Young Actress - Starring in a Television Comedy Series | Married... with Children (1987) | - |
| 1988 | N | Best Young Actress Starring in a New Television Comedy Series | Married... with Children (1987) | - |
| 1987 | W | Exceptional Performance By a Young Actress in a New Television, Comedy or Drama Series | Heart of the City (1986) (TV) | - |
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