Without a Trace is a fast-paced procedural drama about the Missing Persons Squad of the Federal Bureau of Investigation.

Senior agent Jack Malone (Anthony LaPaglia), a tough but compassionate, seasoned and astute professional, heads the dedicated team that knows too well that every second counts when someone vanishes. His squad includes Samantha Spade (Poppy Montgomery), an agent whose blonde good looks belie a tough, complex approach to her work; Vivian Johnson (Marianne Jean-Baptiste), a no-nonsense investigator with a special insight into victims' families; Danny Taylor (Enrique Murciano), whose sensitivity is often covered up by his street smarts; the driven Martin Fitzgerald (Eric Close), whose recent brush with prescription drug addiction revealed a darker side of his straight-laced persona; and the team's newest member, Elena Delgado (Roselyn Sanchez), a resourceful agent who previously worked in the N.Y.P.D.'s Vice unit. As the team members work on varied and complicated cases, details about their own lives continue to unfold.