Set in an urban Pennsylvania neighborhood, "Vampirina" is centered around Vee as she settles into her new surroundings, including making friends and attending a new school. Excited to experience everything that the human world has to offer, Vee will learn that while it may be easier to blend in with her peers, it's important to celebrate the differences that make everyone unique.

Always by her side, Vee's mom and dad are also adapting to their new life as proprietors of the local Scare B&B, a bed and breakfast for visiting ghouls and goblins.