Based on Philip K. Dick's Hugo Award-winning 1962 alternative history, "The Man in the High Castle" considers the question of what would have happened if the Allied Powers had lost World War II. Almost 20 years after that loss, the United States and much of the world has now been split between Japan and Germany, the major hegemonic states.

In season 2, After giving Joe the film, Juliana is forced to flee the fury of the Resistance while embarking on a new path to save her home from destruction. Joe confronts his absent father in Berlin, who is not as he seems. Smith wrestles with what to do about his ill son. Frank takes a gamble with his life in a bid to save Ed. Tagomi's life is turned upside down by his "travel" to an alternative world.

The final season of The Man in the High Castle will be rocked by war and revolution. The Resistance becomes a full-blown rebellion, driven by Juliana Crain's (Alexa Davalos) visions of a better world. A new Black insurgent movement emerges to fight the forces of Nazism and imperialism. As empires teeter, Chief Inspector Takeshi Kido (Joel De La Fuente) will find himself torn between his duty to his country and the bonds of family. Meanwhile, Reichsmarschall John Smith (Rufus Sewell) will be drawn towards the portal the Nazis have built to another universe, and the tantalizing possibility of stepping through a gateway to the path not taken.