"Stan Against Evil" follows Stan Miller (McGinley), a perpetually disgruntled former sheriff of a small New England town who was forced into retirement. Stan has trouble relinquishing his authority to Evie Barret (Varney), the tough and beautiful new sheriff in town, but they form an unlikely alliance when both begin to realize things are not quite right in their quaint New England town. Together, they valiantly fight a plague of unleashed demons that have been haunting the town, which just happens to be built on the site of a massive 17th century witch burning.

The new season picks up where the Season 1 finale cliffhanger left off, with Sheriff Evie Barret (Varney) stranded in the year 1692, accused of being a witch and about to be burned at the stake. Despite his best attempts to never leave his couch, the disgruntled Stan Miller (McGinley) must begrudgingly solve the mystery of Evie's time-travelling disappearance. Throughout the season, the unlikely team will continue to battle against the unconventional demons trying to take over their town, which continue to pop up in every size, shape, and animal-form.