The series revolves around the eccentric residents of a dilapidated former Pennsylvania steel town and the murder of 17-year-old Brooke Bluebell. Through the investigation, the town's seamier side is exposed, revealing that nothing is what it seems.

In the final chapter, Hemlock Grove comes to a riveting and deliciously disturbing conclusion. As the town's grim secrets continue to unravel at an alarming pace, Olivia (Famke Janssen), Roman (Bill Skarsgard), Peter (Landon Liboiron) and Shelley (Madeleine Martin) are introduced to mysterious new people while facing dangerous and unexpected obstacles. As enemies both foreign and familial close in, Peter and Roman learn that in order to prevent the 'end of days,' they will both need to sacrifice their humanity and release their true inner monsters.