"Freakish" centers on a group of students at a small-town high school, who must fight for survival when predatory mutant freaks take over after a meltdown at the local chemical plant.

During Saturday detention, bells ring signaling a containment drill and evacuation - not out of the ordinary for a town with a large chemical plant. The 20 students and the basketball coach retreat to the school fallout shelter for the duration of the drill. Only it's not a drill... When the sirens stop and they return to the school lobby, they find their town has been decimated by an explosion. They see no signs of life outside their high school's front doors. More frightening, those who were not in the bunker appear to be infected...

In season two, the Kent High School students are still trapped inside by the deadly explosion and will find their relationships tested when a new group of survivors arrives. Friendships will be lost, enemies made, and ventures outside into the dangerous unknown will present life and death stakes for the students.