In the premiere episode, John Alden (Shane West) is forced to bury his love Mary Sibley (Janet Montgomery), and her mysterious servant Tituba (Ashley Madekwe) now with the abilities of the seer, has a horrifying vision of hell on earth. She knows the only person who can stop this evil and beat the devil (Oliver Bell) - is the very witch that birthed him, his mother, Mary Sibley. Meanwhile, Isaac (Iddo Goldberg) takes it upon himself to attempt to clean up Knocker's Hole and get revenge against Mercy (Elise Eberle), who has found her calling running the brothel.
Still struggling with her new powers, Anne Hale (Tamzin Merchant) continues to imprison her husband Cotton Mather (Seth Gabel), using her familiar Brown Jenkins. With the help of Baron Sebastian Marburg (Joe Doyle) and his old ally and fallen angel, The Sentinel (Samuel Roukin), the devil is planning a massive attack and war with God that will culminate in the ultimate showdown between good and evil!