The remains of a secret service agent are found in a barrel and Five-0 investigates only to learn that POTUS is en route to the island. Tracking the victim's steps leads the team to a vicious assassin and they determine that although the assassin killed the suspect, a cleaner took care of disposing the body. Five-0 discovers the assassin's target was a witness in a high profile mob case. Racing against the clock, the team manages to take the assassin out. Meanwhile, McGarrett's aunt, Deb, surprises everyone by visiting over Thanksgiving, but after she's arrested for trying to buy marijuana, McGarrett learns that she has advanced brain cancer, is rejecting treatment, and is in town to say goodbye.