When a malfunction occurs aboard the luxury space cruise ship Avenue 5, it's up to engineer Billie McEvoy (Lenora Crichlow) to warn Captain Ryan Clark (Hugh Laurie), Avenue 5 owner Herman Judd (Josh Gad) and his right-hand-woman Iris Kimura (Suzy Nakamura) that the incident may have a cataclysmic knock-on effect.
As Rav Mulcair (Nikki Amuka-Bird) manages the situation from mission control back on Earth, Matt Spencer (Zach Woods), the head of customer relations, tries his best to calm frayed nerves on board, and persistent passenger Karen Kelly (Rebecca Front) discovers the crew may know more than they're letting on.
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