"Good girl" Mary (Jena Malone) and her domineering best friend, Hilary Faye (Mandy Moore), are starting their senior year at the top of the social food chain at American Eagle Christian High School - that is until Mary's boyfriend tells her he thinks he might be gay.
When Jesus appears to her in a vision, she heeds his message to do everything she can to help him and to her horror, she ends up pregnant. Suddenly, Mary begins to question everything she's believed in, and Hilary Faye and her devoted "disciples (including Heather Matarazzo) turn against her. As an outcast, Mary finds herself alone until she's befriended by the school's other pariahs: Hilary Faye's cynical, wheelchair-bound brother, Roland (Macaulay Culkin) the principal's skater heartthrob son, Patrick (Patrick Fugit); and the high school's lone Jew an exuberant rebel named Cassandra (Eva Amurri).
In this sweetly subversive comedy, a group of outsiders band together to navigate the treacherous halls of high school and make it to graduation, ultimately learning more about themselves, finding faith in unexpected places, and realizing what it truly means to be Saved!