"Run Hide Fight" immerses viewers into a day in the life of Zoe Hull (Isabel May), a 17-year-old high school senior who is working through a complex relationship with her father (Thomas Jane) while coping with the recent loss of her mother to cancer. Zoe is just weeks shy of graduating when a quartet of nihilistic classmates siege her high school's cafeteria to perpetrate a mass shooting. She manages to escape the building and help others flee, too, but then realizes she's uniquely prepared to take on the shooters and save lives.