Years ago on a calm, dark night, Dwayne Hopper's life was shattered when his young son Kyle was abducted from his bedroom and disappeared without a trace. Kyle was the the final victim in a string of fourteen local disappearances. Dwayne, his wife Janine and daughter Daisy were forced to abandon hope that he would one day be found.

10 years later...Dwayne remains on the police force, but his family life has crumbled around him. Janine has lost faith in her husband just as Daisy has lost faith in her parents. One fateful night, Dwayne's suspicions are aroused when he notices striking similarities between a current inmate (Perkins), and the purported culprit behind the abductions.

Upon investigation, Dwayne discovers proof of Perkins' guilt during a tense search of the suspect's basement. In a fit of rage, Dwayne kills Perkins, but unbeknownst to him, the fourteen missing victims are very much alive. During captivity, they were dehumanized and trained to kill at random. Perkins' murder ignites a wave of carnage which sweeps across the entire town, with Dwayne's own son as one of the marauding psychopaths.

The Hopper family winds up taking refuge in a barricaded police station - but no walls are able to keep pure evil from breaking through. Dwayne and his family are caught up in a terrifying struggle for survival which pits them against a horde of brainwashed, bloodthirsty, "creatures." Who will survive the night?