"Pandemic" is set in the near future, where a virus of epic proportions has overtaken the planet. There are more infected than uninfected, and humanity is losing its grip on survival. Its only hope is finding a cure and keeping the infected contained. Lauren (Rachel Nichols) is a doctor, who, after the fall of New York, comes to Los Angeles to lead the charge in the hunt for uninfected civilian survivors.

Lauren's objective is simple - lead her team into the field and rescue survivors. Lauren and her team: Gunner (tactical command), Denise (navigation), and Wheeler (driver), put on their anti-contamination suits, complete with cameras so their experiences can be used for research, and leave the compound. But nothing could have prepared them for the mayhem they are about to walk into.