Inventive and wildly fun, NUTS! recounts the mostly-true story of John Romulus Brinkley, a Kansas doctor who in 1917 discovered that he could cure impotence by transplanting goat testicles into men. From there, the story only gets more bizarre.

Mixing hand-drawn animated reenactments, interviews, archival footage, and a highly unreliable narrator, NUTS! traces Brinkley's rise from poverty and obscurity to the heights of celebrity, wealth, and influence.