Ex-boxer Zach (Alex Meraz), talented MMA fighter Tim (UFC fighter Todd Duffee), bullied record store clerk Justin (MMA fighter Scott Epstein), and wrestler Mike (Dean Geyer) come from very different backgrounds, but they share a passion for the "savage science" and quickly become loyal to their unorthodox trainer, Case (Michael Jai White), a brilliant ex-UFC Champion down on his luck.

Teaching them about much more than fighting, Case prepares the young men for a competition called the Beatdown, run by local college kid and fight impresario Max (Evan Peters). When their mentor gets set-up by some bad cops, the young men band together to root out a traitor in their midst.