Gaby (Morris) has been dreading her high school reunion for months. It's not that she's afraid to hang out with the old gang; she's come a long way from her high school tag, "Most Likely To Play the Hand She's Dealt," as she's now one of the top players on the Texas Hold 'Em poker tour. But old grudges die hard, and it seems one of her former friends isn't content to let the past rest in peace.
As the suspense mounts as one by one, Gaby's friends are murdered in a manner that pays gruesome homage to their yearbook superlatives. As the body count climbs, Gaby's forced to admit that one of her friends is a psychotic killer. But who? The Jock? The Class President? The Prankster? With their numbers dwindling, suspicion and mistrust pit friend against friend in a deadly race against time. At this reunion, it doesn't matter what you were voted in high school, as everyone is Most Likely To Die!