"Life Support" follows a manic Roman Catholic family who is preparing for the death of their dying father, Bob (Dennehy) who is in complete denial over his fate, even though he's fully aware of it. Clarke plays Eddie, the son supposedly in charge, isn't ready for any of this, especially having to deal with his mother-in-law, Dawn (Lesley Ann Warren).

Together with his siblings, Eddie struggles over many end-of-life decisions, including potentially pulling the plug should the time come - all in front of a dying Bob, who argues that while he's still alive, he's calling the shots.