"John Sandford's Certain Prey" centers on Lucas Davenport (Harmon), the Deputy Chief of Police for the city of Minneapolis. Davenport doesn't need his job; he could have retired long ago with the money he made designing computer simulations. But Davenport loves what he does just as much as he loves nice suits, fast cars and women. When a cop is shot after witnessing the murder of the wife of a local real estate lawyer, Davenport is called to the scene. The cops quickly zero in on the husband as the prime suspect until a team of FBI agents (or "feebs" as Davenport describes them) descends on Minneapolis with evidence linking the crime to elusive hit woman Clara Rinker (Tatiana Maslany). Taking charge of the investigation, Davenport suspects that Clara is not working alone and sets his sights on Carmel Loan (Lola Glaudini), a high-powered attorney with an intense obsession for the real estate lawyer. As Carmel and Clara try to cover up their crimes, the body count grows and Davenport does what he does best - break all of the rules to nab this deadly duo.