In a distant future where humanity has expanded into the cosmos, "In Space No One Can Hear You Roar" delves into the thrilling survival of a small crew aboard a battered spacecraft. Led by the determined and resilient Captain Mira, portrayed by Emma Stone, the team embarks on what they believe to be a routine mission but soon discovers they are not alone in the vastness of space. As fearsome alien creatures threaten their very existence, each crew member must confront their own fears and insecurities, navigating through tension-filled encounters and haunting secrets that unravel their unity.

Among the crew, the brilliant but troubled engineer, Felix, played by John Boyega, struggles to keep the ship operational while facing his past mistakes, which come back to haunt him at the worst possible moments. Tensions rise as the crew debates whether to abandon ship or confront the lurking menace. The film masterfully balances elements of horror and science fiction, creating an atmosphere thick with dread while exploring themes of courage, trust, and the human spirit's resilience in the darkest of times. As the crew fights for survival, they must learn that sometimes the greatest threats come from within.