Based on a memoir by Dan Marshall, he recounts when he had to move home (into his parents' basement) to help out after his mother faced a cancer relapse and his father was diagnosed with ALS.

Marshall was a college grad, living in Los Angeles, when he had to return, reuniting with his four siblings - all colorful characters with life challenges of their own. Together, the siblings form Team Terminal, going to battle against their parents' illnesses and occasionally each other.