DRIFTER centers on a pair of outlaw brothers, Miles and Dominic Pierce, in a post apocalyptic desert wasteland. They are on their way to kill the man who murdered their father however their mission takes a drastic detour when their car is hijacked causing them to take shelter in the eerie town of Deml.

The brothers quickly discover the town is inhabited by a family of cannibalistic lunatics and their sadistic Mayor, Doyle. Now they must fight for survival to escape the town.