When Jamie invites a complete stranger to come along on a road trip to the north of Chile with his Chilean friend Champa and two of his younger brothers, he fails to realize that this woman -a fellow American who goes by the name of Crystal Fairy- is ready and willing to accept any invitation that comes her way. Jamie's acid and self-absorbed personality clashes with Crystal Fairy's free and esoteric nature as all five of them head into the Atacama Desert with the concise mission of drinking a San Pedro cactus for a mescaline-fueled psychedelic trip. As the journey unfolds and the traveling companions get to know each other better, Jamie must learn that he must be more accepting of others, while Crystal finds the way to accept herself.