"American Night" follows Michael Rubino (Emile Hirsch) who has just become the Don of the New York Mafia, but his greatest dream is to devote his life to painting and become a great artist. John Kaplan (Jonathan Rhys Meyers), an art dealer, may feel like his life is in shambles, but he still has the best eye for spotting fakes in the world. Their paths, apparently distant, cross when Andy Warhol's Pink Marilyn is stolen, setting off a series of unexpected events that upend their lives.