In this intimate and poignant documentary, director Andy Ostroy crafts a moving portrait of his late wife, the vibrant actress and filmmaker Adrienne Shelly. The film explores her journey from a hopeful young actress discovered by indie auteur Hal Hartley to a determined writer-director on the cusp of mainstream success with her final film, Waitress. Through candid interviews with friends and collaborators like Paul Rudd, Keri Russell, Cheryl Hines, and Nathan Fillion, alongside personal archives and the music of Sara Bareilles, a complex and inspiring artist comes to life. "Adrienne" navigates the heartbreaking duality of celebrating a brilliant creative legacy while grappling with a profound personal tragedy, revealing the resilience of a family and the enduring power of art.