In the second half of a two-part episode, Dr. Charlie Harris (Michael Shanks) returns to Hope Zion Hospital to find Dr. Maggie Lin (Julia Taylor Ross) in jeopardy. In a race against time, Charlie struggles to find out what's wrong with his colleague and friend. Meanwhile, Dr. Alex Reid (Erica Durance), who's still dealing with her part in treating the bomber, becomes determined to make amends by saving Maggie's last patient Shelby (Genelle Williams).
Along with Dr. Sydney Katz (Stacey Farber), who returned to Hope Zion for the case, Alex must convince Shelby and her husband that letting go is sometimes the only thing standing in between you and getting better when complications threaten her leg. In the ER, Dr. Cassie Williams (Kim Shaw) and Dr. Jeremy Bishop (Peter Mooney) help a bereaved father deal with the death of his daughter.