Dr. Helen Magnus continues her desperate search for her daughter, Ashley, who is still held prisoner by the Cabal. Together, Magnus and John Druitt interrogate their most elusive contacts around the globe in an attempt to find her and make sense of the Cabal's plan.
Since being captured by the Cabal, Ashley has been undergoing a series of injections and tests resulting in a formidable and alarming transformation. Unbeknownst to the Sanctuary team, her painful and dangerous mutation sets in motion the next phase of the Cabal's destructive mission.
When highly classified information is stolen from a top-secret Interpol location, Magnus is alerted. Will Zimmerman investigates and is surprised to see that it is Ashley on the security tapes pulling off the heist single-handedly. Will finds a connection between the stolen Interpol information and an old case that involved genetic manipulation of five young orphans.
Will and Magnus locate the one remaining test subject not yet captured, and visit his home to bring him to the safety of the Sanctuary. They are greeted at the house by a young woman who seems willing to accommodate them. But they quickly realize they've been tricked by a quick talking con-artist who is making a fast getaway.
Will and Magnus make a swift pursuit. After a dangerous car chase, they corner the woman and force her from her van at gunpoint. While they were able to capture her, she has somehow eluded them with the cargo and the 'orphan' is gone, undoubtedly en route to the Cabal.
In an angry interrogation, Magnus learns they are dealing with Kate Freelander (Agam Darshi), a thief-for-hire with connections to the Cabal. She'll work for whatever side pays her the most and has made a good living eluding authorities and getting what she wants. Despite being under Henry's watchful eye, she is able to make her escape. There's no mistaking she's good at what she does.
Feeling temporarily defeated, the team heads back to the Sanctuary to piece together the new information they have gathered. They start making connections between the orphans, Ashley's disappearance and the Cabal's mysterious ultimate goal.
Kate, meanwhile, makes contact with Cabal leader Dana Whitcomb, demanding payment for her work. But Dana has no intention of paying Kate what she's owed. In fact for allowing herself to be caught, albeit temporarily by Magnus, Kate realizes she is now an enemy of the Cabal and her life is in immediate danger.
Wounded from a violent clash with Cabal agents, Kate is forced to seek refuge at the Sanctuary. Magnus treats her injuries, but shows her no patience and presses for more information on the Cabal and Ashley's whereabouts. Aware that she is no longer safe outside of the Sanctuary, Kate relents and gives up the location of one of the Cabal's facilities.
The team quickly assembles to infiltrate the location in the hope of bringing Ashley home. Teleported there by Druitt, they instead find themselves in a completely empty warehouse. Suddenly, Ashley appears. But she's not the Ashley they know. Void of any emotion, she goes on the attack and the team realizes that they are dealing with a force far more powerful than they could have ever imagined. About to be killed the new Super Abnormal Ashley, they quickly retreat and teleport back to the Sanctuary.
They now painfully understand that this "new" Ashley is under the control of the Cabal and is the pivotal force behind their catastrophic plan to bring down the Sanctuary Network.