Feeling abandoned and alienated by her faith, a shattered and despondent Vanessa (Eva Green) seeks the help of Dr. Seward (Patti LuPone), an American therapist who has an unconventional way of treatment. Meanwhile, now a prisoner under the watchful eye of Scotland Yard Inspector Rusk (Douglas Hodge), Ethan Chandler (Josh Hartnett) is on a train speeding through the desert of the American West. Halfway around the world, in Zanzibar, Sir Malcolm (Timothy Dalton) is confronted by a mysterious Native American man named Kaetenay (Wes Studi) who shares a deep connection with Ethan.
Back in London, Dr. Frankenstein (Harry Treadway) seeks out his old friend Dr. Jekyll (Shazad Latif). With all of her friends scattered around the world facing their own demons, Vanessa is left alone to battle a new evil that has emerged from the shadows.
