A patient's exposure to radiation sends the Night Shift into chaos. Topher (Ken Leung) implements an immediate quarantine and locks down the ER. Paul (Robert Bailey Jr.) cares for the quarantined patient with the help of Ragosa (Freddy Rodriguez) and Kenny (JR Lemon). Meanwhile, TC (Eoin Macken), Drew (Brendan Fehr), and Gwen (Merle Dandridge) race to the site of a multi-victim car cash, where they discover an injured police officer at the heart of the accident. Back at the hospital TC and Jordan (Jill Flint) work desperately to save the officer's life using an unconventional procedure. TC gets an unwelcome surprise when his troubled sister-in-law Annie (guest star Sarah Jane Morris, "NCIS") shows up out of the blue. Still adrift and grieving over the death of her husband, Annie is eager to reminisce with TC about the good old days. Meanwhile, a former patient harasses Jordan, and Drew struggles with his recent breakup. Joey (guest star Adam Rodriguez, "Reckless") pushes Krista (Jeananne Goossen) to take her future into her own hands.
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