Dr. Manning (Torrey DeVitto) and Dr. Charles (Oliver Platt) deal with a 16-year-old patient suffering from abdominal pain who adamantly refuses any drugs for fear of winding up like her drug-addicted father. Dr. Halstead (Nick Gehlfuss) relives a bit of his past when a patient, along with his brother, turn out to be former high school classmates whose past history with him is anything but stellar. Meanwhile, Dr. Choi (Brian Tee) works on a woman 32 weeks pregnant who has a big reason to do everything in her power not to deliver the child, much to the dismay of Goodwin (S. Epatha Merkerson), Charles and the hospital staff.
Elsewhere, April (Yaya DaCosta) is less than thrilled to discover her brother Noah (guest star Roland Buck III) has an enterprising side-business that involves her new boyfriend Tate (guest star Deron J. Powell). Dr. Rhodes (Colin Donnell) avoids meeting up with his sister Claire (guest star Christina Brucato) so he doesn't have to deal with family issues.
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