Dr. Halstead (Nick Gehlfuss) puts both his career and the hospital in jeopardy after he revives a patient with a do-not-resuscitate order. His actions also cause an immediate rift in his relationship with Dr. Manning (Torrey DeVitto), who was strongly against his decision. Goodwin (S. Epatha Merkerson) informs Dr. Halstead that his actions were unacceptable - and that his future at Med may be on the line.
Dr. Choi (Brian Tee) treats a patient with bipolar disorder, and later comes to a disagreement with Dr. Charles (Oliver Platt) over the patient's long-term care. The case hits close to home for Dr. Choi, and he opens up to Dr. Charles about an incident that haunts him from his days in Afghanistan.
Dr. Rhodes (Colin Donnell) is taken under the wing of a famous surgeon-in-residence at the hospital. Though he initially declines the surgeon's offer to learn at his side, Dr. Rhodes changes his mind after learning that the surgeon has a terminal illness.
Sarah (Rachel DiPillo) and April (Yaya DaCosta) bond when they tend to the plight of a homeless man. Later, Sarah is shaken when the homeless man dies peacefully in his sleep.