At the opening day ceremonies for the brand-new Chicago Med Emergency Department, a devastating train crash alerts the medical professionals in attendance that they will soon be engaged in an extreme crisis.
A new staff member and trauma fellow, Dr. Connor Rhodes (Colin Donnell) was on the train when it happened, and he tends to victims as they roll in. Dr. Rhodes crosses paths in the hospital with Dr. Will Halstead (Nick Gehlfuss) - Jay Halstead's (Jesse Lee Soffer) brother from Chicago P.D. - and the two disagree over the diagnosis and treatment of a comatose patient.
As nurses and doctors heal the sick and wounded, we meet other people from Chicago Med. There's Dr. Sarah Reese (Rachel DiPillo), a fourth-year medical student. Her own test in the series premiere is keeping her cool in the heat of extreme pressure... especially after breaking a young child's ribs while administering lifesaving heart compressions. Helping her make it through the day is Dr. Daniel Charles (Oliver Platt), Med's Chief of Psychiatry, with whom she shares a close bond. Dr. Charles finds a fighting chance for a young patient with cystic fibrosis when a victim of the train accident becomes a lifesaving lung donor.
The day pushes everyone to their limits, including Dr. Natalie Manning (Torrey DeVitto), who takes patient after patient despite being in her third trimester of pregnancy. Her best friend is ER Nurse April Sexton (Yaya DaCosta). Dr. Ethan Choi (Brian Tee), a former navy combat doctor, loses a young immigrant patient after a tense day of lifesaving measures.
Sharon Goodwin (S. Epatha Merkerson), the Chief Administrator of Clinical Operations, must balance the life and death decisions made daily by her staff - and the ever-difficult role of keeping an eye on the bottom line of hospital policy.
It is a tough first day at the Chicago Med Emergency Department... but it won't be the last. Tomorrow is a new day, and no matter what it brings, this team will live to fight - and face it - together.
As the Chicago Trilogy shows intertwine, familiar faces from Chicago Fire show up - including Chili (Dora Madison), Brett (Kara Killmer) and Herrmann (David Eigenberg).