When a college Professor opens up a strange, ornate box discovered in the basement of a University, she and her students hear a horrifying scream belonging to that of a bloodthirsty banshee. They think nothing of it, until that scream begins to haunt all that heard it in strange and surreal ways. According to Irish lore, if you hear a Banshee scream, you will die - which is what starts happening to them one by one, as the creature starts taking their lives...