When a cocaine shipment is compromised to the dismay of a drug cartel's CEO, known simply as The Boss (Barry Pepper), he orders his most trusted henchman, The Cook (Nicolas Cage), and his partner, another master drug trafficker known as The Man (Laurence Fishburne), on a dangerous journey to audit the company's supply chain.

As the drugs make their perilous trek across international borders, past gangsters, refiners, and couriers, they are also being tracked by Federal Agents. When The Cook realizes where the network is breaking down, it may be too late to keep the cartel satisfied.