"Run with the Hunted" follows Oscar (Michael Pitt), a young boy who commits a noble murder to save his best friend, Loux (Sam Quartin), and is forced to run away from his hometown and leave her behind. Fifteen years later, he has forgotten his past and turned to a local gang. When his best friend then moves to the city in search of work and takes a job with a private investigator, she stumbles upon his "missing" report and takes it upon herself to find the boy who saved her life.