"Run This Town" follows a naive, young newspaper intern Bram (Ben Platt), who finds himself stuck writing clickbait-y listicles instead of breaking hard-hitting stories like he dreamed of -- until he stumbles upon potentially scandalous information regarding the city's populist mayor, Rob Ford (Damian Lewis).

Sensing an opportunity to prove himself, Bram begins his hasty investigation -- unknowingly linking his life and livelihood to Ford's aides, Kamal (Mena Massoud) and Ashley (Nina Dobrev), who are trying to support their boss while maintaining their integrity. As Bram, Kamal, and Ashley weave their way through a scandal none of them were trained to handle, they struggle to keep their heads above the rising waters of debt, familial pressures, and moral complications.