The story follows brilliant surgeon John Clarke (Huss) who, after a terrible car crash in which his son dies, is tormented by guilt and becomes prey to an unbearable physical pain. While his marriage starts disintegrating, John soon finds out that the only thing that can ease his pain is the taste of human blood.

When he encounters Herb Morris (Bowler), a man who claims he can help him get his life back, John embarks upon a nightmarish journey through which he will either have to come to terms with his pain or become a monster.