Let Me Make a Martyr follows adoptive siblings Drew (Niko Nicotera) and June (Sam Quartin) as they set out to take down a viscous crime ring headed by their adoptive father, Larry (Mark Boone Junior). Set in Tulsa, the two pick up and care for a young girl named Rooney along the way, and in the story that unfolds, the group finds themselves at the prey of a brutal hunt by Pope (Marilyn Manson), a hitman hired by Larry. In the end, the story begins to dive into the surreal.