In Batman and Harley Quinn, Poison Ivy and Jason Woodrue (a.k.a. The Floronic Man) embark on an ecological quest to save the planet - and, unfortunately, eliminate most of humankind along the way. To save humanity, Batman and Nightwing are forced to enlist Harley Quinn to catch Poison Ivy, Harley's BFF and frequent partner-in-crime.

But Batman's patience is put to the test by the unpredictable and untrustworthy Harley during the twists and turns the reluctant companions face during their bumpy road trip. The result is a thrill ride of action, adventure and comedy no Batman fan has seen before.