Mindy is a skilled OB/GYN and shares a practice with a few other doctors, none of whom make life any easier for her. JEREMY REED (British writer/comedian Ed Weeks) is the walking definition of total bad news. He not only shares a practice with Mindy, but sometimes her bed as well - despite her best efforts to resist. He is funny, self-absorbed and super sexy. In contrast, DANNY CASTELLANO (Chris Messina, "Damages") is a hothead and guys' guy who has a habit of stealing Mindy's patients. Danny criticizes her for everything, including her struggling love life and her lack of professionalism - even though it's obvious to everyone except Mindy that he secretly admires her work. His blue-collar childhood gives him a big chip on his shoulder, but he is a dedicated physician, which Mindy can't stand to admit because he's always getting on her case.
Rounding out the office staff are the receptionists - BETSY PUTCH (Zoe Jarman, "Huge"), young, earnest and easily excitable, who thinks the world of Mindy and is always trying to impress her; and SHAUNA DICANIO (newcomer Dana DeLorenzo), a self-assured Jersey Girl who is indifferent to Mindy, always knows where the cool party is and carries a poorly concealed torch for Danny.
Mindy is in constant communication with her beloved best friend from college, GWEN GRANDY (Anna Camp, "The Good Wife"), who also happens to be the governor's daughter. Gwen is a hilarious, sometimes too-blunt friend, and secretly a former carefree party girl (which only Mindy seems to remember). Although Gwen is now happily married to a financial analyst, with a six-year-old daughter, this lawyer-turned-Pilates mom remains squarely in Mindy's corner.
As Mindy attempts to get her career off the ground and meet a guy who passes her red flag test (no drug habits, no skinny jeans and no secret families, among others), only time will tell if she gets her romantic comedy ending.