Set to replace the long-running "Ultimate Spider-Man" animated series, the new Spidey show takes Peter Parker back to his roots as a fifteen-year-old high school student, mirroring the timeline of the upcoming film "Spider-Man: Homecoming". After being bitten by a genetically-modified spider, Peter Parker works to control his new abilities and fights crime as "Spider-Man".

In season 2, It's Peter Parker's sophomore year and he's no longer an inexperienced superhero, or new student at the intimidating Horizon High. With his ever-growing Rogue's Gallery focused on taking him down, Peter must balance working at the Daily Bugle with surviving Doc Ock's attempts to get rid of Spider-Man once and for all!