A mysterious explosion destroys the X-Mansion on the moment that Wolverine was leaving. Professor X and Jean Grey are missing, and perhaps gone for good, causing the X-Men to disband. However, one year later, an anti-mutant group called the Mutant Response Division (or MRD for short) hunt Wolverine and arrest a family that helped him. This causes him to go after them with the help of Beast. Inside the jail, they free all the mutants, including Dust, Boom Boom, and Pyro. In the end, Wolverine decides to find the others X-Men and fight the MRD.