New state laws prohibiting fast food restaurants in low-income neighborhoods result in the closure of all KFC eateries in Colorado, much to the dismay of Cartman, who is addicted to the food. When Randy Marsh learns a former KFC outlet has become a medical cannabis dispensary, he attempts to give himself cancer to get a doctor's referral for marijuana. After placing his testicles into a microwave oven, Randy successfully gives himself testicular cancer, as well as testicles so large he has to use a wheelbarrow to carry them. Randy obtains his medical referral and starts smoking marijuana regularly. Meanwhile, his testicles continue to grow, to the point that he uses them as a space hopper for movement. Randy convinces his friends that women find larger testicles attractive, and they eventually give themselves testicular cancer as well. The local doctor, unaware of the men's self-irradiation, becomes convinced a recent change in South Park is responsible for the cancer outbreak.