Lex (Michael Rosenbaum) has been secretly trying to turn Wes Keenan (guest star Tahmoh Penikett), a military man who supposedly died fighting in Afghanistan, into a "super soldier" by injecting him with DNA pulled from the various meteor freaks he has captured.

After a crooked senator (guest star Alan C. Peterson) threatens to expose his secret labs, Lex dispatches Wes to kill the senator, but Lois (Erica Durance) witnesses the attack and inadvertently becomes the super soldier's next target. Meanwhile, Clark (Tom Welling) tries to convince Lana (Kristin Kreuk) to leave Lex.