Alex (Erica Durance) is still reeling from her breakup with Charlie (Michael Shanks), but when one of the doctors at Hope Zion Hospital asks for her help in dealing with a cancer case, Alex begins research to perform a surgery that could save their life.
However, while trying to help the cancer patient, Alex is surprised to discover that the patient isn't just an anonymous stranger - it's one of her fellow doctors on staff at Hope Zion Hospital.
Meanwhile, Joel (Daniel Gillies) checks in with a former patient - a ballerina whose hip he replaced using a brand new prosthetic from the innovative Sabian Medical Corporation. When the prosthetic proves faulty and kills his patient, Joel's position as Chief of Surgery is jeopardized as he's forced to take on both the powerful company and his former lover, who just happens to work for them.
Charlie attempts to help Joel with his fight, but ends up distracted by the ghost of the ballerina, who has one last wish she needs help fulfilling.