A gas explosion causes a car accident bringing several victims into Miami Trauma One. Just after they save their first victim, their leader, Dr. Rayner, walks out of the trauma room, taking off all his clothes -- the pressures of the job have finally made him crack. With no time to process what just happened, the rest of the team, Dr. Eva Zambrano, Dr. C., Dr. Warren and nurse Tuck, must act quickly to save the rest of the victims, including: a full-term pregnant woman, covered in lacerations from shattered glass; her husband who didn't appear, ends up nearly bleeding out because of a piece of glass lodged in his carotid artery; a man so badly burned in the explosion, he will survive his injuries. The delicate balance of the trauma center is quickly disrupted by the appearance of a new doctor, Dr. Proctor, who ends up being their new team leader.