HIGH PROFILE FEMALE POLITICIAN SIDELINED BY PHILANDERING HUSBAND ACCUSED OF MURDER; DONNA MURPHY AND XANDER BERKELEY GUEST-STAR -- When respected Judge Thomas Layton is killed during a re-creation of the classic Alexander Hamilton/Aaron Burr duel, Detectives Goren (Vincent D'Onofrio) and Eames (Kathryn Erbe) question his dueling partner, George Pagonis (guest star Xander Berkeley, "24") -- who happens to be married to Maureen Pagonis (guest star Donna Murphy, "World Trade Center"), a prominent political candidate and possible first female Mayor of New York.