As TNT's dynamic new series opens, Christina Hawthorne, chief nursing officer for Richmond Trinity Hospital, races to work to try to prevent a suicide attempt by David, an end-stage cancer patient and best friend to her husband. This is the beginning of what is going to be a long day for Christina, a day that happens to be the first anniversary of her husband's death. Putting her mourning on hold, Christina turns her focus to Ray Stein, a nurse who gets into hot water when he goes against his instincts and administers a doctor's questionable treatment; Isabel, a homeless woman who brings a sick infant to the hospital; Camille, Christina's rebellious daughter who has decided to take a stand for free speech in school; and Amanda, Christina's former mother-in-law who also happens to be a member of the hospital board.