One's a Greek. One's a geek. Poised to become the most powerful girl in the Greek system, Casey Cartwright is everything an "it" girl should be: beautiful, vivacious funny warm except to her little brother, Rusty. After a lifetime of geeking out, he sees college as an opportunity to create a whole new identity,He may excel in the honors engineering program, but what the really wants is what other guys have: gals pals an awesome fun time. And to Casey's horrification, he decides to pledge a fraternity.

Casey is horrified at the prospect of her dorky brother ruining her image, and she wants nothing to do with him. But when Rusty sees her boyfriend Evan making it with another girl, the baby brother suddenly seems interesting after all.Oddly enough, she's not the only one interested in Rusty. Evan wants him for his fraternity while Casey's ex-boyfriend Cappie thinks he belongs at his fraternity. His Bible-toting roommate Dale thinks they're all crazy and is praying for Rusty's soul. But the heavens seem to be ignoring his pleas, because Rusty seems destined to become a Greek, no matter how socially inept he is.